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          副研究員

          李焱 副研究員
          副研究員,博士
          E-mail: liyan927818@163.com
           

            2008年畢業于濟寧醫學院,獲臨床醫學學士學位。2011年畢業于上海交通大學醫學院腫瘤研究所,獲腫瘤學碩士學位。2014年畢業于上海交通大學醫學院腫瘤研究所,獲生物化學與分子生物學博士學位。 2014年7月至今就職于復旦大學附屬腫瘤醫院/腫瘤研究所。主持項目包括國家自然科學基金青年項目一項,國家自然科學基金面上項目一項,并作為課題骨干參與國家自然科學基金重點項目及面上項目多項。主要研究成果發表于Cell Research,Cancer Letters, Science Signaling, Cell Death and Disease, Methods in Molecular Biology等專業雜志上 。 


          研究方向:

            1、非編碼RNA (circRNA , miRNA, lncRNA) 在消化道腫瘤中的鑒定、功能及分子機制研究。
            2、腫瘤細胞外泌體中核酸、蛋白的鑒定、功能及其臨床意義。


          代表性論著:

          1. Li Yan#, Chen Bing, Huang Shenglin*. Identification of circRNAs for miRNA Targets by Argonaute2 RNA Immunoprecipitation and Luciferase Screening Assays. Methods Mol Biol, 2018; 1724:209-218.
          2. Jie Chen#, Yan Li#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi*, Shenglin Huang*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters, 2017 Mar 1; 388:208-219.
          3. Zhou Zhenhua#, Li Yan#, Wang Xudong#, Hu Jingjing, Kuang Muyu,Wang Zhiwei, Li Song, Xu Weidong, Xiao Jianru*. ALCAM(+) stromal cells:role in giant cell tumor of bone progression. Cell Death & Disease, 2018 Feb 20; 9(3):299.
          4. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research, 2018 Jan 4; 46(D1):D106-D112.
          5. Zhou Zhenhua# , Li Yan#, Jia Qi# ,Wang Zhiwei, Wang Xudong, Hu Jingjing, Xiao Jianru*. Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells. Cell Prolif, 2017 Aug; 50(4):e12346.   
          6. Zhenhua Zhou#, Yan Li#, Huiqing Wang#, Xudong Wang , Jianru Xiao*. Biological Features of a Renal Cell Carcinoma Cell Line Derived from Spinal Metastasis. DNA Cell Biol, 2017 Feb; 36(2):168-176.
          7. Qiupeng Zheng#, Chunyang Bao#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen,Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications, 2016 Apr 6; 7:11215.
          8. Yan Li#, Qiupeng Zheng#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research, 2015 Aug; 25(8):981-4.
          9. Chunyang Bao#, Yan Li#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling, 2015 Jul 28; 8(387):ra75.  
          10. Li Y#, Xu D#, Bao C#, Zhang Y, Chen D, Zhao F, Ding J, Liang L, Wang Q, Liu L, Li J, Yao M, Huang S*, He X*. MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget, 2015 Feb 10; 6(4):2421-333.
           
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